Research trials only included giving one or two doses of neffy®. As per the ASCIA Action Plan for Anaphylaxis, immediately after the first dose of neffy® an ambulance should be called. If symptoms do not start to improve after 5 minutes, another dose of neffy® (or another adrenaline device) can be given while waiting for an ambulance. Continue to follow your ASCIA Action Plan and take the advice of emergency services.