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Adrenaline (epinephrine) autoinjector use

EpiPen administration 

Adrenaline and temperature control

(Based on data available in 2010)

NOTE: Adrenaline (epinephrine) or adrenaline autoinjector refers to EpiPen®.

Many individuals, parents and caregivers are concerned about the stability of adrenaline in temperatures over 25oC. The Australian climate often takes us beyond 25oC and many have been contacting Allergy & Anaphylaxis Australia (A&AA) with queries on maintaining temperature of the adrenaline autoinjector when they are away from home or when they work outside (e.g. farmer, postman or courier).

It is important to aim to keep your autoinjector between 15 and 25°C most of the time. Obviously weather conditions in Australia are challenging but our aim is to minimise the amount of time that the device is outside these temperature ranges.


  • Adrenaline is light sensitive and so potency (strength) may degrade if exposed to prolonged sun exposure. 

  • The ideal condition for storage is approximately 25°C however fluctuations of +/- 15°C (between 10°C and 40°C are permitted. 

  • Do NOT refrigerate or freeze as it can affect the mechanics of the autoinjector.

Helpful guidelines for temperature management of adrenaline autoinjector:

  • Always keep your adrenaline autoinjector away from direct sunlight

  • If outdoors on a hot day, try to keep it in the shade

  • If you know you are going to be out in the sun for an extended time on a hot day (e.g. at the beach or at a sporting event, when working outside) consider purchasing a Frio wallet which can help maintain the temperature of the autoinjector for up to 45 hours. (see Product Catalogue at

  • Do NOT store your autoinjector in the glove box of your car

  • Do keep it wherever you would prefer to be on a hot day i.e. inside the house, inside the classroom or office or in the shade if you are outside and there is no easily accessible indoor area to keep it

  • Do NOT put it in the fridge, next to an ice pack or on ice although placed in a small esky with cool drinks can also help keep it cool on a very hot day

Content updated June 2017


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